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pentobarbital will lower the extent or result of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Pitolisant exposure is diminished by fifty% if coadministered with robust CYP3A4 inducers.pentobarbital will reduce the extent or impact of estropipate by affecting hepatic/intestinal enzyme CYP3A4 me